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PGD is the genetic evaluation of a preimplantation embryo before transfer to the patient's uterus and subsequent implantation
PGD is offered to carriers of single-gene disorders such a cystic fibrosis, patients with a family or personal history of inheritable disorders, and carriers of abnormal chromosomes
It may also be used to detect or diagnose genetic disorders causing
recurrent pregnancy loss (RPL)
or disorders associated with
increased reproductive age
of the female partner, repeated implantation failure (i.e. multiple failed IVF cycles) and HLA matching
PGD is always used together with
IVF
PGD involves removal of a single cell (a blastomere) from a 6-8 cell embryo to analyze for genetic abnormalities
Biopsied embryos are
allowed to grow to blastocyst stage
Those embryos that are genetically "normal" can be selected for transfer back into the uterus
Limitations of PGD
Requires large enough numbers of embryos to allow transfer at the blastocyst stage
Often, no additional embryos are available for
freezing
Risk of no embryos for transfer
Misdiagnosis
Low risk of damage to the embryo during biopsy
Call for information: (573) 817-3101 or
E-mail us
with questions or comments
